There are several ways to permanently lose the game in Clout, whether it be through assassinations or losing elections.
Lost Election : If you lose an election by losing Constituent Support.
Assassinated: If you are killed by direct PvP missions.
In Prison: If someone gets a critical investigation on you and you have the "Skeletons in your Closet" trait.
First Blood: Reserved for TC01, for being the first to be assassinated.
Shivved: Reserved for those who won election on 1/31/13, but asked for their characters to be deleted. .
Ascended: Given when you die and are promoted to moderator/admin. Only has been given to Geofrey Jenkins and ObviousCheater so far.